Pulmonary hypertension in high-altitude chronic hypoxia: response to nifedipine
نویسندگان
چکیده
منابع مشابه
Pulmonary hypertension in high-altitude chronic hypoxia: response to nifedipine.
Permanent residents at high altitude may develop excessive polycythaemia (H-Hb) and pulmonary hypertension, which often leads to cardiac failure. Inhibitors of calcium channels have been shown to reverse pulmonary hypertension in respiratory diseases and in primary pulmonary hypertension, but their efficiency has not been evaluated in high-altitude-induced pulmonary hypertension. Systolic pulmo...
متن کاملHigh-altitude pulmonary hypertension.
High-altitude pulmonary hypertension (HAPH) is a specific disease affecting populations that live at high elevations. The prevalence of HAPH among those residing at high altitudes needs to be further defined. Whereas reduction in nitric oxide production may be one mechanism for the development of HAPH, the roles of endothelin-1 and prostaglandin I₂ pathways in the pathogenesis of HAPH deserve f...
متن کاملRapid attenuation of response to nifedipine in primary pulmonary hypertension.
In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resis...
متن کاملVentilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema.
Reduced tolerance to high altitude may be associated with a low ventilatory and an increased pulmonary vascular response to hypoxia. We therefore, examined whether individuals susceptible to acute mountain sickness (AMS) or high altitude pulmonary oedema (HAPE) could be identified by noninvasive measurements of these parameters at low altitude. Ventilatory response to hypoxia (HVR) and hypercap...
متن کاملPulmonary hypertension due to chronic hypoxia.
Pulmonary vasoconstriction in response to hypoxia is a basic reflex that occurs in all mammals studied. It has long been thought to have two main physiological functions. In the fetus it is responsible for closing off the pulmonary circulation to prevent blood from shunting through the unventilated lung. After birth it ensures that perfusion is constantly matched to ventilation. The problem com...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 1998
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.98.12051181